A “Blue Moon” is the name given to the second full moon in a calendar month. Since there are roughly 29.5 days between full moons, it is unusual for two full moons to occur in a 30 or 31 day month (and impossible to fit into a 28 or 29 day month, so February can never have a Blue Moon). The saying “Once in a Blue Moon” means a rare occurrence; on average there will be one Blue Moon every 2.5 years. Calico Racing has celebrated the Blue Moon in 2012, 2015, and will again in 2018.
Once in a DOUBLE Blue Moon: In 2018 we will celebrate something truly rare, a situation which only takes place about four times a century: two Blue Moons occurring in the same year. The last time this happened was in 1999, and after 2018 we won’t have a double blue moon again until 2037, 2067, and 2094! Sounds like a good excuse to party!Once in a DOUBLE Blue Moon:
You can choose from the following start times, or DOUBLE DOWN and run both!6:45pm DOUBLE DOWN You may deduct $5 from the combined entry fees if you are running any combination of DAY and NIGHT races. No code required- it is encoded into the online registration platform.When registering online, choose your morning and evening race distances, the $5 multi-event discount will be deducted in your cart.
*ALL raceentries include acustom technical shirt, finishers' medal, event timing, post race food, award eligibility, aid stations, and a fun time!You may deduct $5 from the combined entry fees if you are running any combination of DAY and NIGHT races. No code required- it is encoded into the online registration platform. When registering online, choose your morning and evening race distances, the $5 multi-event discount will be deducted in your cart.
** Those running both AM and PM races will receive 1 shirt and 2 medals !
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Sunset Regional Park : History Walk Trails (Paved)Sunset Regional Park : History Walk Trails (Paved)
2601 East Sunset Road, Las Vegas, NV 89120
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The History Walk paved trails are completely removed from vehicular traffic. The path is mostly flat with only slight inclines/ declines- setting the stage for a PR, or perfect for the beginning runner. The course is walker and stroller friendly. Enjoy views of the Las Vegas Strip, Frenchman's Mountain, landing aircraft, and bunnies!
The detection of somatic point mutations is a key component of cancer genomic research, which has been rapidly developing since next-generation sequencing (NGS) technology revealed its potential for describing genetic alterations in cancer. We present MuSE, a novel approach to mutation calling based on the F81 Markov substitution model for molecular evolution
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, which models the evolution of the reference allele to the allelic composition of the matched tumor and normal tissue at each genomic locus. To improve overall accuracy, we further adopt a sample-specific error model to identify cutoffs, reflecting the variation in tumor heterogeneity among samples.
Source File: https://github.com/danielfan/MuSE
Linux Binary File: MuSEv1.0rc_b MuSEv1.0rc_c
After downloading the source file, for Unix-like operating systems please type the following commands sequentially in the command line to generate the executable:
For Windows, please install Cygwin (
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) first, which provides functionality similar to a Linux distribution on Windows. The following procedures are the same as above.
MuSE is comprised of two steps, which requires
The first step, ‘MuSE call’, takes as input (1) and (2). The BAM files require aligning all the sequence reads against the reference genome using the Burrows-Wheeler alignment tool (BWA), with either the backtrack or the maximal exact matches (MEM) algorithm  . In addition, the BAM files need to be processed by following the Genome Analysis Toolkit (GATK) Best Practices [3-5] that include marking duplicates, realigning the paired tumor-normal BAMs jointly and recalibrating base quality scores.
To speed up ‘MuSE call’, we recommend splitting the WGS data into small blocks (<50Mb) by using the provided option either ‘-r’ or ‘-l’, and concatenating all the output files by the Linux command CAT.
The second step, ‘MuSE sump’, takes as input the output file from ‘MuSE call’ and (3). We provide two options for building the sample-specific error model. One is applicable to WES data (option ‘-E’), and the other to WGS data (option ‘-G’).
The following commands briefly illustrate how to use MuSE. As to the preparation of BAM files, please refer to the first part, PRE-PROCESSING, of the Genome Analysis Toolkit (GATK) Best Practices (
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The Principles and Practice of Engineering (PE) exam tests for a minimum level of competency in a particular engineering discipline. It is designed for engineers who have gained a minimum of four years’ post-college work experience in their chosen engineering discipline.
The PE Civil exam is an 8-hour exam with 80 questions. It is administered in pencil-and-paper format twice per year in April and October. See the
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for specific dates.
Prepare for your exam by
Familiarize yourself with your state licensing board’s unique
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before registering for a PE exam. Special accommodations are available for examinees who meet certain eligibility criteria and sufficiently document their request.
The PE Civil exam is a breadth and depth examination. This means that examinees work the breadth section in the morning and one of the five depth modules in the afternoon. The breadth section contains questions from all five areas of civil engineering. The depth section focuses more closely on a single area of practice.
For details on the format and length of the exam, the topics covered, and applicable design standards, select your engineering discipline below to download the exam specifications. PE exam specifications and design standards are posted 6 months before the exam administration. Updates for the April exams are posted in November, and updates for the October exams are posted in May.
When registering for the PE Civil exam, you will be asked to select an afternoon module. Your answer sheet will be scored based on the module that you selected during registration.
The cost to take the PE exam varies from state to state (or foreign location). Depending on where you register, fees may be paid directly to NCEES, a state licensing board, or a designee of the board. Visit the engineering licensure section, and select your exam location for more information about your registration fees and payees. You may be prompted to contact your state licensing board (or foreign entity) directly.
This pencil-and-paper exam is an open-book exam. You are allowed to bring bound reference materials, but they must remain bound during the exam. Loose paper may be bound with
No staples will be permitted. Sticky notes and flags are permitted only when attached to bound materials. More information is available in the
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