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The 2016 study confirmed that research. Using positron emissiontomography (PET scan) and a special injection of a radioactive material, the researchers were able to get a visual sense of the density of the CB1 receptors in the brain.
The study compared 11 subjects diagnosed with cannabis dependence to 19 volunteers. The images showed that chronic cannabis consumers did, indeed, show lower receptor density. This is an important signifier of tolerance. They then performed these scans again, testing participants during a period of abstinence.
This where the results get interesting. According to the study,
[CB1 downregulation] begins to reverse surprisingly rapidly upon termination of cannabis use and may continue to increase over time.
Amazingly, cannabis tolerance begins to reverse within two days after abstaining from the herb. At the 28-day mark, tolerance continued to improve. This is valuable information for medical cannabis patients, asthis means dosage will change should they stop and start their treatment again.
Though cannabinoid receptors start to spring back just a couple of days after abstaining, the density of CB1 receptors in cannabis consuming participants was still lower than the healthy controls at the four-week mark. Though, should participants continue to abstain, things are predicted to catch up to “normal”.
Many cannabis regulars take tolerance breaks to maintain efficacy with the herb. A tolerance break is a short period of abstinence from the herb. As this study suggests, a mere two days of abstinence seems to be enough to kickstart the upregulation process.
Medical cannabis patients should always work with a health care provider before making major changes to a treatment plan. However, casual cannabis consumers may have a few T-break tricks at their fingers.
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Want to kick your tolerance without much disruption? Start consuming smaller and smaller amounts of cannabis. “Microdosing”, or consuming a very small amount of a substance on a continuous basis, is becoming more popular.
Cannabis tolerance happens when larger and larger amounts of the herb are needed to produce an effect. Switching back to small doses of the plant will not likely be as effective as abstaining. However, it’s a decent compromise for a complete break.
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